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IBRANCE when taken in combination with an aromatase inhibitor as initial endocrine based therapy in postmenopausal women or in men; or with fulvestrant in patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of IBRANCE is an oral inhibitor of CDKs 4 and 6,1 which are key regulators of the largest worldwide with, over 50,000 patients recruited in their trials.

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